Research says... kinda!
This specific toad native to the North American South-West secretes a potent 5ho-DMT, or bufotenin, from the large glands on its head and legs. If you gather that DMT you can smoke it, skyrocketing you to vegetal hyper-space just as if you had extracted it from a plant.
You won't have any trouble identifying B. alvarius. It is the largest native North American species of toad. In terms of snout-to-vent length, B. alvarius requires a minimum of three inches for sexual maturity, although breeding adults continue to grow up to seven inches in length. This desert dweller is of stout build with a squat body and a flat broad head. The skin is smooth and leathery, sparsely covered with pale orange warts, and can change considerably from a dark brown to olive or grayish green. The belly is cream colored and usually unmarked. There are one to four prominent round white warts at the corner of the mouth. But, by far, the most identifying characteristic of B. alvarius is the presence of large granular glands on the neck and limbs.
The granular glands are specialized multi-cellular concentrations of tissue. The most prominent of these is the pair of large kidney-shaped parotoid glands located on on each side of the neck, over and behind the tympanum. Enlarged and enlongated glands on the outside of each hind leg, between the knee and thigh, are called femorals. Similarly, the tibeals are long glands, or a line of shorter ones, that run the full length between the knee and ankle. An additional gland concentration can be found on each of the forearms.
Each of these glands consists of many oval-shaped lobules about two millimeters in diameter. Each lobule is an individual unit with a duct that emerges onto the skin as a well-defined, single pore. A double cell layer surrounds each lobule and functions in the synthesis and release of a viscous milky-white venom.
A subject given 1 mg reported “a tight feeling in the chest” and prickling “as if he had been jabbed by needles.” This was accompanied by a “fleeting sensation of pain in both thighs and a mild nausea.”
Another subject given 2 mg reported “tightness in his throat”. He had tightness in the stomach, tingling in pretibial areas, and developed a purplish hue in the face indicating blood circulation problems. He vomited after 3 minutes.
Another subject given 4 mg complained of “chest oppression” and that “a load is pressing down from above and my body feels heavy.” The subject also reported “numbness of the entire body” and “a pleasant Martini feeling-my body is taking charge of my mind”. The subject reported he saw red spots passing before his eyes and red-purple spots on the floor, and the floor seemed very close to his face. Within 2 minutes these visual effects were gone, and replaced by a yellow haze, as if he were looking through a lens filter.
Fabing and Hawkins commented that bufotenin’s psychedelic effects were "reminiscent of LSD and mescaline but develop and disappear more quickly, indicating rapid central action and rapid degradation of the drug".
Isbell (1956) In 1956, Dr. Harris S. Isbell at the Public Health Service Hospital in Lexington, Kentucky experimented with bufotenine as a snuff. He reported “no subjective or objective effects were observed after spraying with as much as 40 mg bufotenine”; however subjects who received 10–12 mg injected intramuscularly reported “elements of visual hallucinations consisting of a play of colors, lights, and patterns”.
Turner & Merlis (1959) Turner and Merlis (1959) experimented with intravenous administration of bufotenine (as the water soluble creatinine sulfate salt) to schizophrenics at a New York state hospital. They reported that when one subject received 10 mg during a 50-second interval, “the peripheral nervous system effects were extreme: at 17 seconds, flushing of the face, at 22 seconds, maximal inhalation, followed by maximal hyperventilation for about 2 minutes, during which the patient was unresponsive to stimuli; her face was plum-colored". Finally, Turner and Merlis reported that:
“on one occasion, which essentially terminated our study, a patient who received 40 mg intramuscularly, suddenly developed an extremely rapid heart rate; no pulse could be obtained; no blood pressure measured. There seemed to have been an onset of auricular fibrillation…extreme cyanosis developed. Massage over the heart was vigorously executed and the pulse returned to normal…shortly thereafter the patient, still cyanotic, sat up saying: ‘Take that away. I don’t like them’.”After pushing doses to the morally admissible limit without producing visuals, Turner and Merlis conservatively concluded: “We must reject bufotenine…as capable of producing the acute phase of Cohoba intoxication”.
McLeod and Sitaram (1985)A 1985 study by McLeod and Sitaram in humans reported that bufotenine administered intranasally at a dose of 1–16 mg had no effect, other than intense local irritation. When given intravenously at low doses (2–4 mg), bufotenine oxalate caused anxiety but no other effects; however, a dose of 8 mg resulted in profound emotional and perceptual changes, involving extreme anxiety, a sense of imminent death, and visual disturbance associated with color reversal and distortion, and intense flushing of the cheeks and forehead.
Ott (2001) In 2001, ethnobotanist Jonathan Ott published the results of a study in which he self-administered free base bufotenine viainsufflation (5–100 mg), sublingually (50 mg), intrarectally (30 mg), orally (100 mg) and via vaporization (2–8 mg). Ott reported “visionary effects" of intranasal bufotenine and that the "visionary threshold dose" by this route was 40 mg, with smaller doses eliciting perceptibly psychoactive effects. He reported that "intranasal bufotenine is throughout quite physically relaxing; in no case was there facial rubescence, nor any discomfort nor disesteeming side effects".
At 100 mg, effects began within 5 minutes, peaked at 35–40 minutes, and lasted up to 90 minutes. Higher doses produced effects that were described as psychedelic, such as "swirling, colored patterns typical of tryptamines, tending toward the arabesque". Free base bufotenin taken sublingually was found to be identical to intranasal use. The potency, duration, and psychedelic action was the same. Ott found vaporized free base bufotenin active from 2–8 mg with 8 mg producing "ring-like, swirling, colored patterns with eyes closed". He noted that the visionary effects of insufflated bufotenine were verified by one colleague, and those of vaporized bufotenine by several volunteers.
Ott concluded that free base bufotenin taken intranasally and sublingually produced effects similar to those of Yopo without the toxic peripheral symptoms, such as facial flushing, observed in other studies in which the drug was administered intravenously.
"Extracting the venom was somewhat problematic. _Venomous Animals and their Venoms_ gives a procedure where the toad is pressed firmly down with one hand and the paratoidal gland (behind the 'ear') is sqeezed firmly with the other. A piece of glass is suspended above the toad to catch the viscous venom as it squirts from the toad. I found this method awkward. The best way (after brief experimentation) I was able to discover was to hold the toad in one hand, squeeze the gland with the other, and have an assistant hold some glass in the firing line of the paratoidal gland. This should be repeated once after the toad is allowed to rest for 20 minutes or so. You must apply a considerable amount of pressure to release any poison; I was hesitant in this as I was afraid I would injure the toads (especially with the manager standing next to me). Because I didn't apply as much pressure as I should have, I only obtained 80-100 mg of venom from the three toads. According to _Venomous Animals and their Venoms_ I should have obtained something more like 400mg per toad.
In any case, after letting the poison dry, I scraped it off the glass, obtaining a fine crystaline substance. I took 1 gram of Harmala seeds for my experiment (I weigh 160 lbs) and a friend (who weighs 260) took 1.7 grams of the same substance. We also smoked one MJ cigarette. Instead of freebasing the 5-MeO-DMT (as would have been most efficient) we mixed it with some MJ and smoked it in a pipe. The taste was unusual, but not intensely unpleasant. Halfway through smoking the quantity, we stopped. I noticed an odd feeling and slight buzz from the MJ, the freind noticed nothing. We continued smoking, and after finishing both noticed some rather extreme effects.
Objects appeared extremely distorted, colors were intensified and facial quirks were magnified, giving people a clown-like appearance. Perception of distance was extremely disorted; objects within arms reach seemed miles away. Height perceptions were also distorted, one minute I seemed like a giant compared to those around me, the next minute I seemed a dwarf in comparison. Light sources provoked an unusual reaction; they seemed surrounded by moving, prismatic colors. Walking was problematic; the sidewalk reminded me of the famous films of the 'galloping gertie' bridge in washington state. I felt as if I was surfing rather than walking. Observations of the facial expressions of the passerbys seemed to indicate that my manner of walking was no different than that of any of the other pedestrians that night. My freind (who was, for the record, rather out of shape) claimed to experience racing heart, but I had no such difficulties.
After walking for approximately 15 minutes, the intensity of the experience subsided, and we felt able to go to the bar as we had intended. We were both rather strongly intoxicated for the next hour, drinking several beers in that time. Paranoiac feelings, and some mild visual/auditory hallucinations persisted for approximately 2 hours after taking the substance.
Conclusion: the venom of B. Alvarus seems to contain the quantities of 5-MeO-DMT that are claimed for it in the various publications. Its use with harmaline seemed to powerfully increase the already present marijuana intoxication (unlike LSD, which often has an antagonistic effect with THC), as well as provoking uniquely powerful visual hallucinations. The steroidal poisons in the venom _may_ have a toxic cardiac effect when the venom is smoked, or (more likely IMHO, due to my lack of similar reaction) the heart-racing may have been due to the effects of the THC intoxication, or the effects of the 5-MeO-DMT itself. It would probobly be a very bad idea to ingest this substance orally in conjunction with harmaline as a kind of animal ayahuasca; the steroidal poisons are doubtless much more harmful when an orally active dose is taken, due both to the greater quantity that would be required, and to the lack of steroid pyrolysis in an oral dose."
And then it began...My vision went blurry for a split second, and I felt pins and needles creeping quickly up the back of my neck and head. By the time this pins and needles effect got to my eyes, I was tripping VERY hard. Shadows began to move, and slither up my wall. Everything in my room took on a strange glow, and the fear grew inside me. After 20 seconds the effects were still coming on hard and fast, and I felt like I would almost freak out. But then a calm came over me as the drug reached its peak.
The visual effects were similar to a moderate dose of mushrooms or LSD, but the body high was extremely intense. I lay in my bed, hardly moving for about the first minute, time slowed quite dramatically. I was using a winamp visualization program, and it slowed to a crawl, so did my clock. But the music seemed to go on at its normal pace. The only thing I could think for the first 5 minutes was 'Dear God it worked!!.' Everything was so beautiful that it amazed me to no end. I ended up playing with my dog for a while, I really enjoyed touching anything I could get my hands on.
At this dosage, which is quite unknown, I learned nothing spiritual or anything profound. I found this experience to be filled with some neat visuals and mostly just a feeling of “Holy shit”. 5-MeO wears off way to fast; I wished I could have stayed in that bed for much longer. The trip peaked after about 30 seconds, and stayed fairly intense for maybe 5 minutes. The quick decline in effects continued for 20 minutes, but I was left with a nice afterglow. After an hour I felt I was completely back to baseline. My only complaint about the experience is the lingering smell that 5-MeO-DMT leaves. I’d be careful if you are trying to do this while other people are home, the smell stays for hours and would be hard to explain.
Well that’s all I have so far, but I assure you, I WILL be doing this again. Happy toading everyone :-D"
For me personally, I would say just get your DMT experience from plants, no need to harm these animals when a less cruel alternative exists. use mimosa hostilis, acacia confusa, psychotria viridis... those kind of things! Happy readings!